5 edition of Nucleic acid biosynthesis. found in the catalog.
Includes bibliographical references.
|Statement||Edited by Allen I. Laskin and Jerold A. Last.|
|Series||Methods in molecular biology ;, v. 4|
|Contributions||Last, Jerold A., joint author.|
|LC Classifications||QP620 .L37|
|The Physical Object|
|Pagination||x, 276 p.|
|Number of Pages||276|
|LC Control Number||72089529|
Nucleic acids are of nutritive value mainly because of the sugars they contain, namely, ribose and deoxyribose. In the small intestine, pancreatic nucleases (DNAse and RNAse) break down nucleic acids to nucleotides, which are dephosphorylated by alkaline phosphatase to nucleosides; the latter are taken up by sodium-coupled active transport. Biosynthesis of Nucleic Acids - authorSTREAM Presentation. STRUCTURE OF DNA Consists of two strands of nucleotides that form a twisted ladder (double helix) Sugar and phosphate alternate along the sides of the ladder (linked by strong covalent bonds) Pairs of nitrogen bases form the rungs of the ladder (linked by weak hydrogen bonds).
The book contains a useful glossary of nucleic acid terminology, many useful references for further reading and figures to aid understanding of the principles under discussion. Good aspects from the previous edition are retained, including the introductory short historical overview of biological and chemical studies of nucleic s: 6. Membrane-limited structures derived from the plasma membrane or various intracellular membranes which function in storage, transport or metabolism. | Explore the latest full-text research PDFs.
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Nucleic Acid Strands Grow in the 5′ → 3′ Direction. All RNA and DNA synthesis, both cellular and viral, proceeds in the same chemical direction: from the 5′ (phosphate) end to the 3′ (hydroxyl) end (see Figure ).Nucleic acid chains are assembled from 5′ triphosphates of ribonucleosides or deoxyribonucleosides.
Strand growth is energetically unfavorable but is Author: Harvey Lodish, Arnold Berk, S Lawrence Zipursky, Paul Matsudaira, David Baltimore, James Darnell.
Nucleic Acid Biosynthesis in Humans The first step in nucleic acid synthesis involves the formation of the purine and pyrimidine ribonucleotides. There are two endogenous routes: either the energetically expensive de novo route from small molecules such as carbon dioxide, amino acids, and ribose sugars, or the energetically less expensive.
Nucleic acid, naturally occurring chemical compound that is capable of being broken down to yield phosphoric acid, sugars, and a mixture of organic bases (purines and pyrimidines).Nucleic acids are the main information-carrying molecules of the cell, and, by directing the process of protein synthesis, they determine the inherited characteristics of every living thing.
Abstract. Nucleic acids are polymers of nucleotides. The latter are composed of a five-carbon sugar (d-ribose or d-deoxyribose) linked both to a nitrogen base (purine or pyrimidine) and a phosphate group (nucleosides are nucleotides without this phosphate group).The purine and pyrimidine nucleotides which occur most frequently in the nucleic acids of cells are illustrated Cited by: 4.
The Nucleic Acid Biochemistry section contains posts/pages that discuss the basic biochemistry of nucleic acids, the biosynthesis and catabolism of the nucleotides, and the diseases that result as a result of defects in the enzymes of the pathways of nucleotide biosynthesis and.
An ample supply of nucleotides is Nucleic acid biosynthesis. book for many life processes. First, nucleotides are the activated precursors of nucleic acids.
As such, they are necessary for the replication of the genome and the transcription of the genetic information intoan adenine nucleotide, ATP, is the universal currency of energy.
A guanine nucleotide, GTP, also serves as an. The antimicrobial actions of these agents are a result of differences in prokaryotic and eukaryotic enzymes involved in nucleic acid synthesis.
Prokaryotic transcription is the process in which messenger RNA transcripts of genetic material are produced for later translation into proteins. BIOSYNTHESIS OF NUCLEIC ACID% I ity that the paths of metabolism and the precursors for purines may be dif- these different animals.
Since the work to be discussed below was first described (l), Marsh (13) has reported that formate is a precursor of nucleic acid. ADVERTISEMENTS: In this article we will discuss about the process of biosynthesis of nucleic acids.
Biosynthesis of Nucleosides-5′-Triphosphates: Among animals, some amino acids cannot be synthesized and must therefore be supplied through diet (essential amino acids). On the contrary, purine and pyrimidine nucleotides can be synthesized “de novo”, from precursors. The reader is methodically introduced to the structure and biosynthesis of RNA and DNA; nucleic acids found in viruses; and biosynthesis of mononucleotides.
An account of nucleases and related enzymes is also given. A chapter on the precise mechanism by which nucleic acids are broken down in the cell concludes the book. Overview Overview Broad sense of metabolism Breakdown (salvage pathway) Synthesis (bases, nucleotides, strands) Nucleotide & strand structures How replication and transcription work Nucleic acid structure Bases Purines: adenosine & guanosine Pyrimidines: cytosine, uracil & thymine Ribose 5-carbon sugar (pentose) Carbon naming system uses “primes” DNA is 2′.
Additional Physical Format: Online version: Laskin, Allen I., Nucleic acid biosynthesis. New York, M. Dekker, (OCoLC) Online version. Synthesis of Oligonucleotides Carrying Nucleic Acid Derivatives of Biomedical and Structural Interest (Pages: ) Ramon Eritja; Anna Aviñó; Carme Fàbrega; Adele Alagia; Andreia F.
Jorge; Santiago Grijalvo. The Nucleic Acids, Volume III covers the significant progress in understanding the chemistry and biological importance of the nucleic acids.
This volume is composed of 12 chapters, and begins with an overview of the general principles of the determination of weight, shape, and dimension of large molecules in Edition: 1. Nucleic acid - Nucleic acid - Nucleic acid metabolism: Replication, repair, and recombination—the three main processes of DNA metabolism—are carried out by specialized machinery within the cell.
DNA must be replicated accurately in order to ensure the integrity of the genetic code. Errors that creep in during replication or because of damage after replication.
Nucleic Acids Book. A free online book on the chemistry and biology of nucleic acids, written by Prof. Tom Brown and Dr Tom Brown (Jnr). The book is ideal for chemistry and biology students and also provides practical information for researchers working in the lab.
Nucleic acid. 1 Chapter 14 Lecture Notes: Nucleic Acids Educational Goals 1. Know the three chemical components of a nucleotide: a monosaccharide residue (either ribose or deoxyribose), at least one phosphate group, and an “organic base.” 2.
Identify phosphoester bonding patterns and N-glycosidic bonds within nucleotides. Compare and contrast ribonucleotides and. The nucleus contains the cell’s DNA, which makes up the genome. The nucleus is surrounded by a nuclear envelope, two membrane bilayers Molecules come into and out of the nucleus through nuclear pores The inside of the nucleus is called the nucleoplasm.
Chromatin is the name given to DNA complexed with proteins (histones) The nucleolus is a region where. Nucleic acids are the biopolymers, or large biomolecules, essential to all known forms of term nucleic acid is the overall name for DNA and RNA.
They are composed of nucleotides, which are the monomers made of three components: a 5-carbon sugar, a phosphate group and a nitrogenous the sugar is a compound ribose, the polymer is RNA (ribonucleic acid); if.
Salvage pathways recycle the free bases and nucleosides released from nucleic acid break down both types of pathways are important in cellular metabolism. Two major routes for nucleotide biosynthesis dNTPs dNTPs Stryer Fig. Lipid Metabolism R G Langdon, and and A H Phillips Annual Review of Biochemistry Nucleic Acids, Purines, Pyrimidines (Nucleotide Synthesis) S C Hartman, and and J M Buchanan Annual Review of Biochemistry Metabolism of Nucleic Acids E S CanellakisCited by: Book: Biochemistry Online (Jakubowski) a key biosynthetic intermediate in nucleic acid synthesis as well as erthyrosephosphate used for biosynthesis of aromatic amino acids.
The oxidative branch is important in reductive biosynthesis as it is a major source of the reductant NADPH used in biosynthetic reactions. The reader is methodically introduced to the structure and biosynthesis of RNA and DNA; nucleic acids found in viruses; and biosynthesis of mononucleotides.
An account of nucleases and related enzymes is also given. A chapter on the precise mechanism by which nucleic acids are broken down in the cell concludes the Edition: 1.